ABSTRACT
BACKGROUND: Natural honey is widely used all over the world as a complementary and alternative medicine in various disorders including Fanconi anemia (FA). FA is a rare genetic chromosomal instability syndrome caused by impairment of DNA repair and reactive oxygen species (ROS) imbalance. This disease is also related to bone marrow failure and cancer. The aim of this study was to evaluate the cytoprotective effect of honey on mitomycin C (MMC-) induced chromosomal damage in peripheral lymphocytes from FA patients. MATERIALS AND METHODS: Treatment of these complications with alkylation agents MMC may enhance chromosomal breakage. We have evaluated the effect of honey on MMC- induced chromosomal breakage in FA blood cells using chromosomal breakage assay. The basal chromosomal breakage count was higher among FA patients than healthy subjects. RESULTS: The addition of MMC alone gave a significantly higher of chromosomal breakage in FA patients than control group (P < 0.0001). Pre- treatment with honey significantly inhibited breakage induced by MMC in FA patients by its antioxidant effect. CONCLUSION: Honey can prevent MMC- induced chromosomal breakage by its antioxidant effect.
Subject(s)
Adolescent , Child , Chromosome Breakage/drug effects , Chromosome Breakage/genetics , Female , Honey/therapeutic use , Humans , Male , Mitomycin/adverse effectsABSTRACT
Le miel est utilise dans le traitement des plaies depuis la haute antiquite. Son utilisation se poursuit dans les pays africains et indo-pakistanais ou les plaies infectees constituent un probleme majeur de sante dans les populations rurales. Depuis deux ans; les auteurs testent l'efficacite du miel sur les plaie de nature diverses. Ils rapportent dans ce travail; les resultats preliminaires de leur etude